Abstract: Disorders of the lower gastrointestinal (GI) tract can pose a major determinant to quality of life. Gastrointestinal tract motility and inflammatory disorders can significantly affect an individual's sense of well-being and social interactions. Many women turn to their obstetrician-gynecologists for primary and preventive care, or they come to obstetric-gynecologic offices with vague concerns that overlap with many gynecologic disorders. Often, the obstetrician-gynecologist is the physician who prompts women to obtain screening examinations for colorectal cancer, thus knowledge of current screening recommendations is essential. Lower GI tract disorders can affect and also be affected by pregnancy and fertility. Common GI tract disorders, including colorectal cancer, motility and functional disorders, and inflammatory bowel disease, are reviewed in this monograph. Because most obstetrician-gynecologists will encounter these entities frequently in their practices, their context in women's health, including pregnancy, are addressed.